cAMP-responsive element [CRE] modulator (CREM)

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Introduction

Like CREB, CREM binds to CRE & to AP1 sites. In contrast to CREB, CREM down regulates cAMP-induced transcription. Also in contrast to CREB, expression is cell-specific. May form heterodimers with other CRE-binding proteins.

More general terms

References

  1. Foulkes NS, Borrelli E, Sassone-Corsi P. CREM gene: use of alternative DNA-binding domains generates multiple antagonists of cAMP-induced transcription. Cell. 1991 Feb 22;64(4):739-49. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1847666
  2. Foulkes NS, Laoide BM, Schlotter F, Sassone-Corsi P. Transcriptional antagonist cAMP-responsive element modulator (CREM) down-regulates c-fos cAMP-induced expression. Proc Natl Acad Sci U S A. 1991 Jun 15;88(12):5448-52. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1647033
  3. Stehle JH et al Adrenergic signals direct rhythmic expression of transcriptional repressor CREM in the pineal gland. Nature. 1993 Sep 23;365(6444):314-20. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8397338

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