Ca+2/calmodulin-dependent protein kinase type 1G; CaM kinase 1 gamma; CaM kinase 1G; CaM-K1 gamma; CaMK1 gamma; CaMK1G; CaMK-like CREB kinase 3; CLICK 3 (CAMK1G, VWS1)

Function

• Ca+2/calmodulin-dependent protein kinase
• component of a Ca+2-triggered signaling cascade (putative)
• in vitro, phosphorylates transcription factor CREB1
• activated by Ca+2/calmodulin
• binding of calmodulin is thought to result in a conformational change & leads to activation through phosphorylation by CAMKK1
• may be prenylated on Cys-473

Structure

• the autoinhibitory domain overlaps with the calmodulin- binding region & interacts in the inactive folded state with the catalytic domain as a pseudosubstrate (putative)
• belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family, CaMK subfamily
• contains 1 protein kinase domain

Compartment

• cytoplasm, Golgi membrane, plasma membrane protein (putative)

Alternative splicing

named isoforms=2

Expression

• mainly expressed in brain
  • strongly expressed in forebrain neocortex, striatum & limbic system
• low expression in skeletal muscles, kidney, spleen & liver

More general terms

• Ca+2/calmodulin-dependent protein kinase (CaM kinase)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=57172
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:57172
• UniProt: http://www.uniprot.org/uniprot/Q96NX5.html