histone deacetylase 6 (HDAC6)

Function

• see histone deacetylase
• deacetylation of Lys on N-terminal part of core histones (H2A, H2B, H3 & H4)
• role in microtubule-dependent cell motility via deacetylation of tubulin
• interacts with CBFA2T3, HDAC11 & SIRT2
• interacts with F-actin
• ubiquitinated
• polyubiquitination does NOT lead to its degradation
• sumoylated in vitro

Structure

• belongs to the histone deacetylase family, type 2 subfamily
• contains 1 UBP-type Zn+2 finger

Compartment

• nucleus, cytoplasm
• mainly cytoplasmic, where it is associated with microtubules

More general terms

• histone deacetylase
• phosphoprotein
• zinc finger protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q9UBN7.html
• OMIM: https://mirror.omim.org/entry/300272
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10013