histone deacetylase 11 (HDAC11, HD11)

Function

• see histone deacetylase
• deacetylation of Lys on N-terminal part of core histones (H2A, H2B, H3 & H4)
• interacts with HDAC6

Inhibition:

• activity is inhibited by trapoxin, a known histone deacetylase inhibitor

Structure

belongs to the histone deacetylase family

Compartment

nucleus, predominantly nuclear

Expression

• weakly expressed in most tissues
• strongly expressed in brain, heart, skeletal muscle, kidney & testis

More general terms

• histone deacetylase

Database

• OMIM: https://mirror.omim.org/entry/607226
• UniProt: http://www.uniprot.org/uniprot/Q96DB2.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=79885