zinc finger E-box-binding homeobox 2; zinc finger homeobox protein 1b; smad-interacting protein 1; SMADIP1 (ZEB2, KIAA0569, SIP1, ZFHX1B, ZFX1B, HRIHFB2411)

Function

• transcriptional inhibitor that binds to DNA sequence 5'-CACCT-3' in different promoters. represses transcription of E-cadherin
• sumoylation on Lys-391 & Lys-866 is promoted by the E3 SUMO-protein ligase CBX4, & impairs interaction with CTBP1 & transcription repression activity
• binds activated SMAD1, activated SMAD2 & activated SMAD3; binding with SMAD4 is not detected (putative)
• interacts with CBX4 & CTBP1

Structure

• belongs to the delta-EF1/ZFH-1 C2H2-type Zn+2-finger family
• contains 7 C2H2-type Zn+2 fingers
• contains 1 homeobox DNA-binding domain

Compartment

• nucleus

Pathology

• defects in ZEB2 are the cause of Mowat-Wilson syndrome

More general terms

• homeobox protein
• C2H2 type zinc finger protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9839
• OMIM: https://mirror.omim.org/entry/235730
• OMIM: https://mirror.omim.org/entry/605802
• UniProt: http://www.uniprot.org/uniprot/O60315.html