protein Wiz (widely-interspaced zinc finger-containing protein, zinc finger protein 803, WIZ, ZNF803)

Function

• may link EHMT1 & EHMT2 histone methyltransferases to the CTBP corepressor machinery
• role in EHMT1-EHMT2 heterodimer formation & stabilization (putative)
• interacts with EHMT1, EHMT2, CTBP1 & CTBP2

Structure

• belongs to the krueppel C2H2-type zinc-finger protein family
• contains 11 C2H2-type zinc fingers C2H2-type zinc finger 11 mediates interaction with EHMT1 & EHMT2

Compartment

nucleus

Alternative splicing

named isoforms=2

More general terms

• C2H2 type zinc finger protein
• phosphoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/O95785.html