forkhead box protein P1 (FOXP1)

Function

• transcriptional repressor
• role in specification & differentiation of lung epithelium
• can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential
• forms homodimers & heterodimers with FOXP2 & FOXP4
• dimerization is required for DNA-binding
• interacts with CTBP1

Structure

• contains 1 C2H2-type zinc finger
• contains 1 fork-head DNA-binding domain
• leucine-zipper is required for dimerization & transcriptional repression

Compartment

nucleus

Alternative splicing

named isoforms=4

More general terms

• forkhead family transcription factor
• C2H2 type zinc finger protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q9H334.html
• OMIM: https://mirror.omim.org/entry/605515