retinoblastoma-binding protein 8; RBBP-8; CtBP-interacting protein; CtIP; retinoblastoma-interacting protein & myosin-like; RIM (RBBP8, CTIP)

Function

• may modulate function of BRCA1 in transcriptional regulation, DNA repair, &/or cell cycle checkpoint control
• interacts with CTBP, with the C-terminal (BRCT) domains of BRCA1, & with Rb1
• phosphorylated upon DNA damage, probably by ATM or ATR
• hyperphosphorylation upon ionizing radiation results in dissociation from BRCA1
• ubiquitination mediated by SIAH1 leads to proteasomal degradation (probable)

Compartment

nucleus, predominantly nuclear

More general terms

• retinoblastoma-binding protein
• phosphoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5932
• OMIM: https://mirror.omim.org/entry/604124
• UniProt: http://www.uniprot.org/uniprot/Q99708.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5932