etropic viral integration site 1 protein homolog; evi-1 protein; MDS1 & EVI1 complex locus protein EVI1 (EVI-1, EVI1, MECOM)
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Function
- may interact with CTBP1 (putative)
- phosphorylated upon DNA damage, probably by ATM or ATR
Structure
contains 10 C2H2-type Zn+2 fingers
Compartment
Alternative splicing
named isoforms=2
Pathology
- chromosomal translocation t(3;21)(q26;q22) involving EVI1 with RUNX1/AML1 is a cause of acute myelogenous leukemia (AML)
More general terms
- DNA-binding protein
- transcription factor (TF)
- C2H2 type zinc finger protein
- phosphoprotein
- proto oncogene protein
References
- ↑ UniProt http://www.uniprot.org/uniprot/Q03112.html
- ↑ Hunter T. Cooperation between oncogenes. Cell. 1991 Jan 25;64(2):249-70. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1988147
- ↑ Atlas of genetics & cytogenetics in oncology & haematology http://atlasgeneticsoncology.org/genes/EVI103q26ID19.html