AML1 or CBFA2 gene
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Introduction
The AML1 gene on chromosome 21 encodes a protein with a central 118-amino-acid domain with 69% homology to the Drosophila pair- rule gene, runt. AML1 is disrupted in chromosomal translocations associated with acute myelogenous leukemia:
More general terms
References
- ↑ Meyers et al, Identification of AML-1 and the (8;21) translocation protein (AML-1/ETO) as sequence-specific DNA-binding proteins: the runt homology domain is required for DNA binding and protein- protein interactions. Mol Cell Biol 13(10):6336 1993 PMID: https://www.ncbi.nlm.nih.gov/pubmed/8413232