protein CBFA2T1; protein MTG8; protein ETO; Eight twenty one protein; cyclin-D-related protein; zinc finger MYND domain-containing protein 2 (RUNX1T1, AML1T1, CBFA2T1, CDR, ETO, MTG8, ZMYND2)

Function

• transcription factor (putative)
• binds to histone deacetylases & transcription factors
• can repress transactivation mediated by TCF12 homotetramer, & heterotetramer with CBFA2T2 & CBFA2T3
• interacts with TCF12, SIN3A, HDAC1, HDAC2, HDAC3, NCOR1 & NCOR2

Structure

• the TAFH domain mediates interaction with transcription regulators
• belongs to the CBFA2T family
• contains 1 MYND-type Zn+2 finger
• contains 1 TAFH (NHR1) domain

Compartment

nucleus (putative)

Alternative splicing

named isoforms=2

Expression

• expressed in brain > lung, heart, testis, ovary

Pathology

• chromosomal translocation t(8;21)(q22;q22) involving ETO with RUNX1/AML1 is a cause of acute myeloid leukemia (AML-M2)
• defects in RUNX1T1 may be a cause of colorectal adenocarcinoma

More general terms

• nuclear protein
• zinc finger protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=862
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:862
• OMIM: https://mirror.omim.org/entry/114500
• OMIM: https://mirror.omim.org/entry/133435
• UniProt: http://www.uniprot.org/uniprot/Q06455.html