transcription factor 12; helix loop helix transcription factor-4; transcription factor HTF-4; E-box-binding protein; DNA-binding protein HTF4 (TCF12; HEB; HTF4)

Function

• binds specifically to oligomers of E-box motifs
• may play important roles during development of the nervous system as well as in other organ systems
• efficient DNA binding requires dimerization with another bHLH protein
• forms homo- or heterooligomers with myogenin, E12 & ITF2 proteins
• interacts with PTF1A (putative)
• phosphorylated upon DNA damage, probably by ATM or ATR

Structure

contains 1 basic helix-loop-helix (bHLH) domain

Compartment

nucleus

Expression

• expressed in several tissues & cell types including skeletal muscle, thymus, & a B-cell line

More general terms

• basic helix loop helix (bHLH) family transcription factor
• phosphoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/Q99081.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6938
• OMIM: https://mirror.omim.org/entry/600480