chromosomal translocation t(8;21)(q22;q22) (AML-M2)

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[1][2]

Introduction

Translocation described as t8q22:21q22 resulting in over- expression of c-mos serine/threonine kinase. However c-mos maps to 8q11 (confusion regarding the c-mos locus in the past, see OMIM for c-mos). Found in acute myeloid leukemias particularly AML-M2, 18-40% of cases depending on reference []2].

More general terms

References

  1. ↑ Cotran et al Robbins Pathologic Basis of Disease, W.B. Saunders Co, Philadelphia, PA 1989 pg 288
  2. ↑ Yergeau et al. Nature Genetics 15:303-6, 1997
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