transcription factor E2F8 (E2F-8, E2F8)
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Function
- inhibitor of E2F-dependent transcription
- binds DNA independently of DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3'
- appears to regulate a subset of E2F-dependent genes whose products are required for normal cell cycle progession
- modulates activity of other E2F proteins, including E2F1, probably by competing or displacing activating E2Fs from promoter binding
- self-associates (putative)
- probably binds DNA as a homodimer
Structure
- both DNA-binding domains are required for DNA-binding & are proposed to form an intramolecular structure that is similar to the winged helix structure of the E2F-DP heterodimer
- belongs to the E2F/DP family