activating transcription factor 7-interacting protein 2 (MBD1-containing chromatin-associated factor 2, ATF7IP2, MCAF2)

Function

• recruiter that couples transcriptional factors to general transcription apparatus & thereby modulates transcription regulation & chromatin formation
• can both act as an activator or a repressor depending on the context
• mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1
• complex formed with MBD1 & SETDB1 represses transcription & probably couples DNA methylation & histone Lys-9 trimethylation activity
• interacts with MBD1, SETDB1 & SP1.
• probably forms a complex with SETDB1 & MBD1

Structure

• belongs to the MCAF family -contains 1 fibronectin F3 module

Compartment

nucleus

Alternative splicing

named isoforms=2

More general terms

• transcription factor (TF)

Additional terms

• activating transcription factor 7-interacting protein 1 (ATFa-associated modulator, hAM, ATF-IP, ATF-interacting protein, MBD1-containing chromatin-associated factor 1, P621, ATF7IP, MCAF, MCAF1)

Database

• UniProt: http://www.uniprot.org/uniprot/Q5U623.html