methyl-CpG-binding domain protein 1 (methyl-CpG-binding protein MBD1, protein containing methyl-CpG-binding domain 1, MBD1, PCM1)

Function

• binds CpG islands in promoters where DNA is methylated at position 5 of cytosine within CpG dinucleotides
• binding abolished by the presence of 7-mG produced by DNA damage by methylmethanesulfonate
• transcriptional repressor, gene silencing
• isoforms 1 & 2 can repress transcription from unmethylated promoters - binding via third CXXC-type zinc finger
• binds OASL, ATF7IP, CHAF1A, SUV39H1-CBX5 complex binds MGP via TRD domain
• component of MeCP1 complex (putative)
• up-regulated by interferon

Compartment

• nucleus, nuclear speckle
• associated with euchromatic regions of chromosomes, pericentromeric regions on chromosome 1 & telomeric regions of several chromosomes

Alternative splicing

named isoforms=7

Expression

widely expressed

More general terms

• methyl-CpG binding domain protein
• zinc finger protein

Database

• OMIM: https://mirror.omim.org/entry/156535
• UniProt: http://www.uniprot.org/uniprot/Q9UIS9.html