59 kD 2'-5'-oligoadenylate synthase-like protein; thyroid receptor-interacting protein 14; TR-interacting protein 14; TRIP-14; p59 OASL; p59OASL (OASL, TRIP14)

Function

• does not have 2'-5'-oligoadenylate synthase activity, but binds double-stranded RNA & DNA
• specifically interacts with the ligand binding domain of the thyroid receptor
• TRIP14 does not require the presence of thyroid hormone for its interaction
• binds MBD1

Structure

• belongs to the 2-5A synthase family
• contains 2 ubiquitin-like domains

Alternative splicing

named isoforms=2

Expression

• expressed in most tissues
• highest expression in peripheral blood Leukocytes & other hematopoietic tissues, colon, stomach
• lesser expression in testis
• induced by interferons

Comparative biology

• this may not be the true ortholog of mouse OASL

More general terms

• thyroid hormone receptor interacting protein (TRIP)
• DNA-binding protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8638
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8638
• OMIM: https://mirror.omim.org/entry/603281
• UniProt: http://www.uniprot.org/uniprot/Q15646.html