activating transcription factor 7-interacting protein 1 (ATFa-associated modulator, hAM, ATF-IP, ATF-interacting protein, MBD1-containing chromatin-associated factor 1, P621, ATF7IP, MCAF, MCAF1)

Function

• recruiter that couples transcriptional factors to general transcription apparatus & thereby modulates transcription regulation & chromatin formation
• can both act as an activator or a repressor depending on the context
• mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1
• required to stimulate histone methyltransferase activity of SETDB1 & facilitate the conversion of dimethylated to trimethylated H3 Lys-9
• complex formed with MBD1 & SETDB1 represses transcription & couples DNA methylation & histone Lys-9 trimethylation interacts with MBD1; the interaction is enhanced when MBD1 is sumoylated
• probably forms a complex with SETDB1 & MBD1
• interacts with SUMO ubiquitin-like proteins (SUMO1, SUNO2 & SUMO3), with a preference for SUMO2 & SUMO3
• interacts with SP1, ATF7 & ZHX1

Structure

belongs to the MCAF family contains 1 fibronectin F3 module

Compartment

nucleus

Alternative splicing

named isoforms=3

Pathology

• interacts with Epstein-Barr virus BRLF1/Rta protein, leading to promote & regulate host genes in Epstein- Barr virus- infected cells

More general terms

• transcription factor (TF)
• phosphoprotein

Additional terms

• activating transcription factor 7-interacting protein 2 (MBD1-containing chromatin-associated factor 2, ATF7IP2, MCAF2)

Database

• UniProt: http://www.uniprot.org/uniprot/Q6VMQ6.html