transgenic mouse model HuAPPsw

Introduction

Transgenic mouse model overexpressing human amyloid precursor protein (APP). A human Swedish double mutant APP gene is expressed in neurons under the control of the hamster prion gene promoter. The 2 mouse APP genes are also present.

More general terms

• transgenic mouse

Additional terms

• CD230 or major prion protein (PrP)
• Swedish FAD double mutation (FAD1)