APP knockout mouse

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Introduction

APP knockout mice do not exhibit early mortality, but display some abnormalities.

The phenotype is characterized by:[1]

It is suggested that APP is one of a family of proteins (the APLP family of proteins) with overlapping function, thus the apparent non essentiality of a single member of the family.[2]

More general terms

Additional terms

References

  1. 1.0 1.1 Kamal A, Almenar-Queralt A, LeBlanc JF, Roberts EA, Goldstein LS. Kinesin-mediated axonal transport of a membrane compartment containing beta-secretase and presenilin-1 requires APP. Nature. 2001 Dec 6;414(6864):643-8. PMID: https://www.ncbi.nlm.nih.gov/pubmed/11740561
  2. 2.0 2.1 Selkoe DJ. Alzheimer's disease: genes, proteins, and therapy. Physiol Rev. 2001 Apr;81(2):741-66. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/11274343