thimet oligopeptidase; endopeptidase 24.15; MP78 (THOP1)

Function

• role in the metabolism of neuropeptides < 20 aa residues
• role in cytoplasmic peptide degradation
• able to degrade the beta-amyloid precursor protein & generate amyloidogenic fragments
• preferential cleavage of bonds with hydrophobic residues at P1, P2 & P3' & a small residue at P1' in substrates of 5-15 residues

Cofactor: binds 1 Zn+2 per subunit (putative)

Structure

• monomer (putative)
• belongs to the peptidase M3 family

Compartment

cytoplasm

More general terms

• metalloprotease
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7064
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7064
• OMIM: https://mirror.omim.org/entry/601117
• UniProt: http://www.uniprot.org/uniprot/P52888.html