ankyrin repeat & sterile alpha motif domain-containing protein 1B (amyloid-beta protein intracellular domain-associated protein 1, AIDA-1, E2A-PBX1-associated protein, EB-1, ANKS1B)

^[1]

Function

isoform 2 may participate in the regulation of nucleoplasmic coilin protein interactions in neuronal & transformed cells
isoform 3 can regulate global protein synthesis by altering nucleolar numbers (putative)
isoform 4 may play a role as a modulator of APP processing
overexpression of isoform 4 can down-regulate APP processing
isoform 3 interacts with DLG4 (putative)
interacts with EPHA8
isoform 2 interacts with COIL
isoform 4 interacts with APP & EPHA8
isoform 6 interacts with EPHA8
nuclear translocation of isoform 3 requires an NMDAR- dependent proteolytic cleavage (putative)

contains

cytoplasm
isoform 2: nucleus
isoform 3: cell junction, synpase, postsynaptic membrane, postsynaptic density, cell projection, dendritic spine
synaptic localization requires DLG4 interaction
nucleus, Cajal body
translocation to the nucleus in response to stimulation of NMDA receptors (NMDARs) is Ca+2-independent (putative)
isoform 4: nucleus
interaction with APP causes its partial exclusion from the nucleus, when APP is overexpressed
nucleus

highly expressed in marrow from patients with pre-B ALL associated with the t(1;19) translocation
strongly expressed in brain & testis
expressed in fetal brain
isoform 4 is highly expressed in brain (at protein level)
isoform 6 is expressed in brain & several cancer cell lines
transcriptionally up-regulated in t(1:19) pre-B cell acute lymphocytic leukemia by the chimeric TCF3-PBX1
not expressed in pre-B cell that lack this translocation