ephrin type-A receptor 8; ephA8 receptor; tyrosine-protein kinase receptor EEK; EPH- & ELK-related kinase; HEK3 (EPHA8, EEK, KIAA1459)

Function

• receptor for members of the ephrin-A family
• interacts with FYN (putative)
• interacts with ANKS1B
• phosphorylation on Tyr-616 is critical for association with FYN (putative)
• phosphorylation on Tyr-839 modulates tyrosine kinase activity

Structure

• belongs to the protein kinase superfamily, Tyr protein kinase family, Ephrin receptor subfamily
• contains 2 fibronectin F3 modules
• contains 1 protein kinase domain
• contains 1 SAM (sterile alpha motif) domain

Compartment

membrane

More general terms

• ephA receptor

Database

• OMIM: https://mirror.omim.org/entry/176945
• UniProt: http://www.uniprot.org/uniprot/P29322.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2046