collagen 25 alpha-1; CLAC-P; Alzheimer disease amyloid-associated protein; AMY; contains: collagen-like Alzheimer amyloid plaque component (CLAC) (COL25A1)

Function

• inhibits fibrillization of beta amyloid peptide during elongation
• assembly of amyloid fibrils into protease-resistant aggregates
• binds heparin
• binds to fibrillized forms of beta amyloid peptide 40 & more frequently with beta amyloid peptide 42
• glycosylated

Structure

• forms homodimers & homotrimers
• hydroxylated on 11% of PRO & 49% of LYS
• contains 7 collagen-like domains

Compartment

• membrane
• after proteolytic cleavage, CLAC is secreted

Alternative splicing

named isoforms=3

Expression

expressed predominantly in brain

Pathology

• deposited in primitive or neuritic amyloid plaques
• proteolytic cleavage by furin protease to yield soluble collagen-like Alzheimer amyloid plaque component

More general terms

• collagen subunit
• glycoprotein
• membrane protein

Additional terms

• A4 amyloid peptide; beta-peptide
• amyloid precursor protein; A4/beta amyloid precursor protein (APP)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=84570
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:84570
• OMIM: https://mirror.omim.org/entry/610004
• UniProt: http://www.uniprot.org/uniprot/Q9BXS0.html