N-lysine methyltransferase SETD8; H4-K20-HMTase SETD8; histone-lysine N-methyltransferase SETD8; lysine N-methyltransferase 5A; PR/SET domain-containing protein 07; PR-Set7; PR/SET07; SET domain-containing protein 8 (SETD8, KMT5A, PRSET7, SET07, SET8)

From Aaushi
Jump to navigation Jump to search

Function

S-adenosyl-L-methionine + L-lysine-[[[A137031|histone]]] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[[[A137031|histone]]]

Structure

Compartment

Alternative splicing

named isoforms=2

Expression

Notes

More general terms

References

  1. UniProt http://www.uniprot.org/uniprot/Q9NQR1.html
  2. 2.0 2.1 2.2 Kumamoto University Cellular senescence prevented by the SETD8 enzyme Science Daily. March 8, 2017 https://www.sciencedaily.com/releases/2017/03/170308092443.htm
    Tanaka H, Takebayashi S, Sakamoto A et al The SETD8/PR-Set7 Methyltransferase Functions as a Barrier to Prevent Senescence-Associated Metabolic Remodeling. Cell Reports, 2017; 18 (9): 2148 PMID: https://www.ncbi.nlm.nih.gov/pubmed/28249161 Free Article

Database