pituitary-specific positive transcription factor 1; PIT-1; growth hormone factor 1; GHF-1 (POU1F1, GHF1, PIT1)
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Function
- transcription factor involved in the specification of the lactotrope, somatotrope, & thyrotrope phenotypes in the developing anterior pituitary
- activates growth hormone & prolactin genes
- specifically binds to the consensus sequence 5'-TAAAT-3'
Structure
- belongs to the POU transcription factor family, class-1 subfamily
- contains 1 homeobox DNA-binding domain
- contains 1 POU-specific domain
Compartment
Alternative splicing
named isoforms=2
Pathology
- defects in POU1F1 are a cause of familial combined pituitary hormone deficiency
More general terms
Additional terms
References
- ↑ Monuki ES, Kuhn R, Weinmaster G, Trapp BD, Lemke G. Expression and activity of the POU transcription factor SCIP. Science. 1990 Sep 14;249(4974):1300-3. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1975954
- ↑ Li S, Crenshaw EB 3rd, Rawson EJ, Simmons DM, Swanson LW, Rosenfeld MG. Dwarf locus mutants lacking three pituitary cell types result from mutations in the POU-domain gene pit-1. Nature. 1990 Oct 11;347(6293):528-33. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1977085
- ↑ Entrez Gene http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5449
- ↑ UniProt http://www.uniprot.org/uniprot/P28069.html
- ↑ GeneReviews https://www.genecards.org/cgi-bin/carddisp.pl?gene=POU1F1