histone acetyltransferase MYST4; MYST-4; histone acetyltransferase MORF; histone acetyltransferase MOZ2; MOZ, YBF2/SAS3, SAS2 & TIP60 protein 4; monocytic leukemia zinc finger protein-related factor (MYST4, KIAA0383, MORF, MOZ2, KAT6B)

Function

• positive & negative regulation of transcription; N-terminus is involved in transcriptional activation; C-terminus is involved in transcriptional repression
• RUNX2-dependent transcriptional activation
• development of cerebral cortex
• interacts with RUNX1 & RUNX2

acetyl-CoA + histone <--> CoA + acetylhistone

Compartment

nucleus

Alternative splicing

named isoforms=3

Expression

• ubiquitously expressed
• highest levels in heart, pancreas, testis, ovary

Pathology

• chromosomal translocation t(10;16)(q22;p13) with CREBBP associated with acute myeloid leukemia

More general terms

• histone acetyltransferase
• C2H2 type zinc finger protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=23522
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:23522
• OMIM: https://mirror.omim.org/entry/605880
• UniProt: http://www.uniprot.org/uniprot/Q8WYB5.html