familial platelet disorder with associated myeloid malignancy

Pathology

• qualitative & quantitative platelet defects
• propensity to develop acute myelogenous leukemia

Genetics

• autosomal dominant
• associated with defects in RUNX1

Laboratory

• CBC may show thrombocytopenia
• platelet aggregation may be abnormal

Complications

• propensity to develop acute myelogenous leukemia

More general terms

• genetic disease of the blood/bone marrow

Database

• OMIM: https://mirror.omim.org/entry/601399