platelet disorder; thromboasthenia
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Etiology
- platelet adhesion defects
- platelet aggregation defects
- platelet release defects
- anti-platelet drugs
- non-steroidal anti-inflammatory drugs (NSAIDs) (most common acquired qualititative platelet defect)
- glycoprotein IIb/IIIa inhibitors
- P2Y12 receptor inhibitors
- granule storage pool defects
- congenital
- acquired
- uremia
- platelet coating
- anti-platelet drugs
- platelet coagulant defect
- Scott's syndrome
- other congenital platelet defects[1]
- Wiskott-Aldrich syndrome
- gray platelet syndrome
- congenital cyclo-oxygenase inhibition/deficiency
- other acquired platelet defects
- liver disease
- myeloproliferative disease
- post cardiac bypass
- disorders associated with thrombocytosis
- thrombocytopenia
Epidemiology
- only von-Willebrand's disease is common
- all other platelet disorders (excepting drug induced) are rare
Clinical manifestations
- mucosal bleeding is characteristic
Laboratory
- complete blood count (CBC)
- platelet count may be normal
- bleeding time may be prolonged
- INR & aPTT normal
- von Willebrand factor (vWF) may be abnormal
- platelet aggregometry may be abnormal
- see ARUP consult[3]
Management
- epsilon-aminocaproic acid used to treat platelet defects due to
More general terms
More specific terms
- acquired platelet aggregation disorder
- Bernard-Soulier disease (giant platelet syndrome, benign Mediterranean macrothrombocytopenia)
- Epstein syndrome
- Glanzmann's thrombasthenia
- gray platelet syndrome
- macrothrombocytopenia with sensorineural deafness
- Quebec platelet disorder
- Sebastian syndrome
- storage pool disease
- thrombocytopenia
- thrombocytosis (thrombocythemia)
- von-Willebrand's disease (vWD)
Additional terms
References
- ↑ 1.0 1.1 Medical Knowledge Self Assessment Program (MKSAP) 11, 16, 17, 18. American College of Physicians, Philadelphia 1998, 2012, 2015, 2018
- ↑ Harrison's Principles of Internal Medicine, 13th ed. Isselbacher et al (eds), McGraw-Hill Inc. NY, 1994, pg 321
- ↑ 3.0 3.1 ARUP Consult: Functional Platelet Disorders The Physician's Guide to Laboratory Test Selection & Interpretation https://www.arupconsult.com/content/functional-platelet-disorders
- ↑ Burrows RF. Platelet disorders in pregnancy. Curr Opin Obstet Gynecol. 2001 Apr;13(2):115-9. PMID: https://www.ncbi.nlm.nih.gov/pubmed/11315863
- ↑ Konkle BA. Acquired disorders of platelet function. Hematology Am Soc Hematol Educ Program. 2011;2011:391-6. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/22160063
- ↑ Mohan G, Malayala SV, Mehta P, et al. A comprehensive review of congenital platelet disorders, thrombocytopenias and thrombocytopathies. Cureus. 2020;12:e11275. PMID: https://www.ncbi.nlm.nih.gov/pubmed/33274150