acquired platelet aggregation disorder

Etiology

• associated disorders
  • uremia
  • myeloproliferative disorders
  • monoclonal gammapathies
  • chronic liver disease
  • cardiopulmonary bypass
• antiplatelet agents
  • aspirin & other nonsteroidal anti-inflammatory drugs (NSAIDs)
  • glycoprotein IIb/IIIa inhibitors
    • abciximab, eptifibatide, tirofiban
  • P2Y12 inhibitors
    • clopidogrel, ticgrelor, prasugrel
• other pharmaceuticals
  • high-dose penicillin
  • beta-lactam antibiotics

Management

• DDAVP of benefit in patients with renal failure

More general terms

• platelet disorder; thromboasthenia