abciximab (ReoPro)

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Introduction

Fab fragment of chimeric human-murine monoclonal antibody 7E3.

Tradename: ReoPro.

Indications

Contraindications

Caution:

Dosage

Liquid: 2 mg/mL, 5 mL.

Pharmacokinetics

Monitor

Adverse effects

Mechanism of action

More general terms

Additional terms

References

  1. The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996
  2. Kaiser Permanente Northern California Regional Drug Formulary, 1998
  3. 3.0 3.1 Journal Watch 22(6):47, 2002 Boersma E, Harrington RA, Moliterno DJ, White H, Theroux P, Van de Werf F, de Torbal A, Armstrong PW, Wallentin LC, Wilcox RG, Simes J, Califf RM, Topol EJ, Simoons ML. Platelet glycoprotein IIb/IIIa inhibitors in acute coronary syndromes: a meta-analysis of all major randomised clinical trials. Lancet. 2002 Jan 19;359(9302):189-98. Erratum in: Lancet 2002 Jun 15;359(9323):2120. PMID: https://www.ncbi.nlm.nih.gov/pubmed/11812552
  4. 4.0 4.1 Kandzari DE, Hasselblad V, Tcheng JE, Stone GW, Califf RM, Kastrati A, Neumann FJ, Brener SJ, Montalescot G, Kong DF, Harrington RA. Improved clinical outcomes with abciximab therapy in acute myocardial infarction: a systematic overview of randomized clinical trials. Am Heart J. 2004 Mar;147(3):457-62. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/14999194
  5. Department of Veterans Affairs, VA National Formulary
  6. 6.0 6.1 Ndrepepa G, Kastrati A, Mehilli J, Neumann FJ, ten Berg J, Bruskina O, Dotzer F, Seyfarth M, Pache J, Dirschinger J, Ulm K, Berger PB, Schomig A. Age-dependent effect of abciximab in patients with acute coronary syndromes treated with percutaneous coronary interventions. Circulation. 2006 Nov 7;114(19):2040-6. Epub 2006 Oct 23. PMID: https://www.ncbi.nlm.nih.gov/pubmed/17060377
    Montalescot G. Glycoprotein IIb/IIIa inhibitors in the elderly: fear of age or age of fear? Circulation. 2006 Nov 7;114(19):2004-6. PMID: https://www.ncbi.nlm.nih.gov/pubmed/17088473
  7. 7.0 7.1 7.2 Medical Knowledge Self Assessment Program (MKSAP) 14, 16, 18 American College of Physicians, Philadelphia 2006, 2013, 2018.
  8. 8.0 8.1 Deprecated Reference