polycomb group protein ASXL2 (ddditional sex combs-like protein 2, ASXL2, ASXH2, KIAA1685)

Function

• putative polycomb group (PcG) protein
• phosphorylated upon DNA damage, probably by ATM or ATR

Structure

• contains two Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs, which may be required for an association with nuclear receptors
• belongs to the Asx family
• contains 1 PHD-type Zn+2 finger

Compartment

nucleus (probable)

Alternative splicing

named isoforms=2

Pathology

• chromosomal translocation t(2;8)(p23;p11.2 involving ASXL2 with MYST3 is a cause of therapy-related myelodysplastic syndrome
• the translocation generates a MYST3-ASXL2 fusion protein

More general terms

• nuclear protein
• phosphoprotein
• zinc finger protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q76L83.html