Geminin (GMNN)
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Function
- inhibits DNA replication by preventing the incorporation of MCM complex into prereplication complex (pre-RC)
- degraded during the mitotic phase of the cell cycle
- ubiquinated by anaphase-promoting complex
- its degradation at the metaphase-anaphase transition permits replication in the succeeding cell cycle
- interaction with CDT1 inhibits binding of the MCM complex to origins of replication
Structure
- homotetramer
- belongs to the geminin family
Compartment
Expression
- absent during G1 phase, accumulates during S phase, G2 phase, & M phase, & disappears at the time of the metaphase- anaphase transition
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/O75496.html
- ↑ McGarry TJ & Kirschner MW. Geminin, an inhibitor of DNA replication, is degraded during mitosis. Cell 93:1043-53, 1998 PMID: https://www.ncbi.nlm.nih.gov/pubmed/9635433
- ↑ Wohlschlegel JA et al. Inhibition of eukaryotic DNA replication by geminin binding to Cdt1. Science 290:2309-12, 2000 PMID: https://www.ncbi.nlm.nih.gov/pubmed/11125146
- ↑ Lygerou Z & Nurse P. Cell cycle. License withheld--geminin blocks DNA replication. Science 290: 2271-3, 2000 PMID: https://www.ncbi.nlm.nih.gov/pubmed/11188727