Tob1 protein; transducer of erbB-2 1 (TOB1, TOB, TROB1)

Function

• anti-proliferative protein that interacts with the erbB2
• may interact with other protein-tyrosine kinase receptors
• phosphorylated on Ser & Thr
• interacts with CNOT7

Structure

belongs to the BTG family

Expression

ubiquitous

More general terms

• phosphoprotein

Additional terms

• receptor tyrosine-protein kinase erbB-2; p185erbB2; C-erbB-2; NEU proto-oncogene; tyrosine kinase-type cell surface receptor HER2; MLN 19; CD340 (ERBB2, HER2, NEU, NGL)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10140
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10140
• OMIM: https://mirror.omim.org/entry/605523
• UniProt: http://www.uniprot.org/uniprot/P50616.html