F-box only protein 7 (FBXO7, FBX7)

Function

• substrate recognition component of SCF complex
• BIRC2 & DLGAP5 protein modification; protein ubiquitination
• interacts via its C-terminal proline-rich region with DLGAP5
• interacts with BIRC2

Structure

contains 1 F-box domain

Pathology

• defects in FBXO7 are the cause of Parkinson disease type 15

More general terms

• F-box only protein

Component of

• SCF-type E3 ligase complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=25793
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:25793
• OMIM: https://mirror.omim.org/entry/260300
• OMIM: https://mirror.omim.org/entry/605648
• UniProt: http://www.uniprot.org/uniprot/Q9Y3I1.html