discs large homolog 7; disks large-associated protein 5; DAP-5; disks large-associated protein DLG7; hepatoma up-regulated protein; HURP (DLGAP5, DLG7, KIAA0008)
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Function
- regulation of cell cycle (putative)
- mitotic phosphoprotein regulated by ubiquitin-proteasome pathway
- regulation of adherens junction
- CDH1-mediated adhesion & signaling in epithelial cells
- interacts with CDC2, CDH1
- interacts with C-terminal proline-rich region of FBXO7
- recruited by FBXO7 to a SKP1-CUL1-F-box protein complex (CDK1/cyclin B-phosphorylation dependent)
- ubiquitinated, leading to its degradation
- phosphorylated upon DNA damage, probably by ATM or ATR
- decreased phosphorylation levels associated with differentiation of intestinal epithelial cells
Structure
belongs to the SAPAP family
Compartment
- nucleus, cytoplasm
- localizes to spindle in mitotic cells
- colocalizes with CDH1 at sites of cell-cell contact in intestinal epithelial cells
Alternative splicing
named isoforms=2
Expression
- expressed in fetal liver > bone marrow, testis, colon, placenta
- increased expression in G2/M phase of synchronized cultures of HeLa cells
Pathology
- may play a role in carcinogenesis
More general terms
Additional terms
- discs large homolog
- disks large-associated protein 1; DAP-1; guanylate kinase-associated protein; hGKAP; SAP90/PSD-95-associated protein 1; SAPAP1; PSD-95/SAP90-binding protein 1 (DLGAP1 DAP1 GKAP)
- drosophila discs large [dlg] protein