F-box only protein 4 (FBXO4, FBX4)

Function

• substrate recognition component of a SCF complex
• probably recognizes & binds to phosphorylated target proteins
• recognizes TERF1 & promotes its ubiquitination together with UBE2D1
• protein modification; protein ubiquitination directly interacts with SKP1A & CUL1

Structure

contains 1 F-box domain

Alternative splicing

named isoforms=2

More general terms

• F-box only protein
• phosphoprotein

Component of

• SCF-type E3 ligase complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=26272
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:26272
• OMIM: https://mirror.omim.org/entry/609090
• UniProt: http://www.uniprot.org/uniprot/Q9UKT5.html