F-box only protein 11; vitiligo-associated protein 1; VIT-1 (FBXO11, FBX11, VIT1, UG063H01)

Function

• substrate recognition component of the SCF complex
• probably recognizes & binds to phosphorylated target proteins
• binds to & neddylates phosphorylated TP53/p53, inhibiting its transcriptional activity
• SCF(FBXO11) does not seem to direct ubiquitination of TP53
• interacts with TP53

Structure

• contains 1 F-box domain
• contains 19 PbH1 repeats
• contains 1 UBR-type Zn+2 finger

Compartment

nucleus

Alternative splicing

named isoforms=5

Expression

• isoform 5 is expressed in keratinocytes, fibroblasts & melanocytes

More general terms

• F-box only protein
• zinc finger protein

Component of

• SCF-type E3 ligase complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=80204
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:80204
• OMIM: https://mirror.omim.org/entry/607871
• UniProt: http://www.uniprot.org/uniprot/Q86XK2.html