F-box only protein 32; muscle atrophy F-box protein; MAFbx; atrogin-1 (FBXO32)

Function

• substrate recognition component of SKP1-CUL1-F-box protein (SCF) complex, an E3 ubiquitin-protein ligase complex which mediates ubiquitination & subsequent proteasomal degradation of target proteins
• probably recognizes & binds to phosphorylated target proteins during skeletal muscle atrophy
• recognizes TERF1 protein modification; protein ubiquitination

Structure

contains 1 F-box domain

Expression

• specifically expressed in cardiac & skeletal muscle

Pathology

• upregulated with muscle atrophy

More general terms

• F-box only protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=114907
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:114907
• OMIM: https://mirror.omim.org/entry/606604
• UniProt: http://www.uniprot.org/uniprot/Q969P5.html