F-box only protein 25 (FBXO25, FBX25)

Function

• substrate-recognition component of the SCF complex
• directly interacts with SKP1A & CUL1

Structure

contains 1 F-box domain

Compartment

nucleus

Alternative splicing

named isoforms=3

Expression

expressed in all brain tissue observed

Pathology

• chromosomal translocation t(X;8)(p11.22;p23.3) involving FBXO25 with SHROOM4 is a cause of X-linked mental retardation

More general terms

• F-box only protein

Component of

• SCF-type E3 ligase complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=26260
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:26260
• OMIM: https://mirror.omim.org/entry/609098
• UniProt: http://www.uniprot.org/uniprot/Q8TCJ0.html