F-box/WD repeat-containing protein 7; F-box & WD-40 domain-containing protein 7; F-box protein FBX30; Archipelago homolog; hAgo; SEL-10; hCdc4 (FBXW7, FBW7, FBX30, SEL10)

Function

• substrate recognition component of a SCF complex
• probably recognizes & binds to phosphorylated target proteins
• involved in the degradation of cyclin E, NOTCH1 released notch intracellular domain (NICD), & probably PSEN1
• phosphorylated upon DNA damage, probably by ATM or ATR
• interacts with PSEN1, cyclin E, NOTCH1 NICD, NOTCH4 NICD & SKP1A

Structure

• contains 1 F-box domain
• contains 7 WD repeats

Compartment

nucleus (putative)

Alternative splicing

named isoforms=4

Expression

• isoform 1 is widely expressed
• isoform 4 is expressed in brain

More general terms

• F-box & WD-repeat protein
• phosphoprotein

Component of

• SCF-type E3 ligase complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=55294
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:55294
• OMIM: https://mirror.omim.org/entry/606278
• UniProt: http://www.uniprot.org/uniprot/Q969H0.html