ubiquitin/ISG15-conjugating enzyme E2 L6; retinoic acid-induced gene B protein; RIG-B; UbcH8; ubiquitin carrier protein L6; ubiquitin-protein ligase L6 (UBE2L6, UBCH8)

Function

• catalyzes the covalent attachment of ubiquitin or ISG15 to other proteins
• functions in the E6/E6-AP-induced ubiquitination of p53/TP53
• protein modification; protein ubiquitination
• ISGylated
• interacts with RNF19A, RNF19B & RNF144B

Structure

• belongs to the ubiquitin-conjugating enzyme family

Alternative splicing

named isoforms=2

Expression

• present in natural killer cells (at protein level)
• induced by IFNB1/IFN-beta

More general terms

• ubiquitin-conjugating protein E2 (ubiquitin carrier protein)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9246
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9246
• OMIM: https://mirror.omim.org/entry/603890
• UniProt: http://www.uniprot.org/uniprot/O14933.html