stress-induced-phosphoprotein 1; STI1; Hsc70/Hsp90-organizing protein; Hop; transformation-sensitive protein IEF SSP 3521; NY-REN-11 antigen (STIP1)

Function

• mediates the association of the molecular chaperones HSC70 & HSP90 (HSPCA & HSPCB)
• forms a complex with HSC70 & HSPCA/HSP-86 & HSPCB/HSP-84
• interacts with PACRG

Structure

• the TPR repeat 1 interacts with the C-terminal of HSC70
• the TPR repeats 4, 5 & 6 (also called TPR2A domain) & TPR repeats 7, 8 & 9 (also called TPR2B domain) interact with HSP90
• contains 2 STI1 domains
• contains 9 TPR repeats

Compartment

• cytoplasm (putative)
• nucleus

More general terms

• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10963
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10963
• OMIM: https://mirror.omim.org/entry/605063
• UniProt: http://www.uniprot.org/uniprot/P31948.html