deleted in colon cancer (DCC); netrin receptor DCC; tumor suppressor protein DCC; colorectal cancer suppressor; immunoglobulin superfamily DCC subclass member 1 (DCC, IGDCC1)

Function

• receptor for netrin required for axon guidance
• mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding
• association with UNC5 proteins may trigger signaling for axon repulsion
• required for apoptosis induction when not associated with netrin ligand
• tumor suppressor gene
• interacts with cytoplasmic part of UNC5A, UNC5B, UNC5C & probably UNC5D
• ubiquitination mediated by SIAH1 or SIAH2, leading to its subsequent proteasomal degradation

Structure

• belongs to the immunoglobulin superfamily, DCC family
• contains 6 fibronectin F3 modules
  • contains 4 Ig-like C2-type domains (immunoglobulin-like)

Compartment

membrane

Expression

• found in axons of the central & peripheral nervous system & in differentiated cell types of the intestine

Pathology

• colorectal tumors that lost their capacity to differentiate into mucus producing cells uniformly lack DCC expression
• inactivation of DCC due to allelic deletion &/or point mutations may cause both lymphatic & hematogenous metastasis of esophageal squamous cell carcinomas

More general terms

• anti-oncoprotein (tumor suppressor protein)
• netrin receptor
• glycoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/P43146.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1630
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1630
• OMIM: https://mirror.omim.org/entry/120470