netrin receptor UNC5C (Unc-5 homolog C, Unc-5 homolog 3, UNC5C, UNC5H3)

Function

• receptor for netrin
• involved in axon guidance
• mediates axon repulsion of neuronal growth cones in developing nervous system
• association with DCC (cytoplasmic domain) may trigger signaling for axonal repulsion
• corticospinal tract axon guidance, independent of DCC
• apoptosis induction when NOT associated with netrin
• phosphorylated on different cytoplasmic Tyr
• phosphorylation of Tyr-568 leads to an interaction with PTPN11 phosphatase (netrin-dependent)
• proteolytic cleavage by caspases during apoptosis does NOT occur associated with netrin ligand
• cleavage by caspases is required to induce apoptosis

Structure

• belongs to the unc-5 family
• contains 1 death domain
• contains 1 Ig-like (immunoglobulin-like) domain
• contains 1 Ig-like C2-type domain (immunoglobulin-like)
• contains 2 TSP type-1 domains
• contains 1 ZU5 domain

Compartment

membrane

Alternative splicing

named isoforms=2

Expression

• expressed in brain, kidney
• not expressed in developing or adult lung

Pathology

• down-regulated in multiple cancers including
  • colorectal cancer
  • breast cancer
  • ovarian cancer
  • uterine cancer
  • stomach cancer
  • lung cancer
  • kidney cancer

More general terms

• UNC5 homolog protein
• glycoprotein
• phosphoprotein

Additional terms

• netrin

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8633
• OMIM: https://mirror.omim.org/entry/603610
• UniProt: http://www.uniprot.org/uniprot/O95185.html