netrin receptor UNC5B (Unc-5 homolog B, Unc-5 homolog B, UNC5B, UNC5H2, p53-regulated receptor for death & life protein 1, P53RDL1, UNQ1883/PRO4326)

Function

• receptor for netrin
• involved in axon guidance
• mediates axon repulsion of neuronal growth cones in developing nervous system
• association with DCC (cytoplasmic domain) may trigger signaling for axonal repulsion
• apoptosis induction when NOT associated with netrin
• interacts with GNAI2
• induction by p53
• phosphorylated on cytoplasmic Tyr
• proteolytic cleavage by caspases during apoptosis does NOT occur associated with netrin ligand
• cleavage by caspases is required to induce apoptosis

Compartment

membrane

Alternative splicing

named isoforms=2

Expression

• expressed in brain > developing lung, cartilage, kidney, hematopoietic & immune tissues

Pathology

• down-regulated in multiple cancers including colorectal cancer breast cancer ovarian cancer uterine cancer stomach cancer lung cancer kidney cancer

More general terms

• UNC5 homolog protein
• glycoprotein
• phosphoprotein

Additional terms

• netrin

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=219699
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:219699
• OMIM: https://mirror.omim.org/entry/607870
• UniProt: http://www.uniprot.org/uniprot/Q8IZJ1.html