netrin receptor UNC5A (Unc-5 homolog A, Unc-5 homolog 1, UNC5A, UNC5H1, KIAA1976)

Function

• receptor for netrin
• involved in axon guidance
• mediates axon repulsion of neuronal growth cones in developing nervous system
• association with DCC (cytoplasmic domain) may trigger signaling for axonal repulsion
• apoptosis induction when NOT associated with netrin
• interacts with MAGED1 mediated by ZU5 domain
  • participates in the induction of apoptosis
• interacts with PRKCABP,
  • regulates its surface expression & leads to its removal from surface of neurons & growth cones
• phosphorylated on different cytoplasmic Tyr
• phosphorylated by PKC in vitro
• phosphorylation of Tyr-568 leads to an interaction with PTPN11 phosphatase (netrin-dependent)
• proteolytic cleavage by caspases during apoptosis does NOT occur associated with netrin ligand
• cleavage by caspases is required to induce apoptosis

Compartment

membrane

Alternative splicing

named isoforms=3

Expression

• expressed in brain, kidney
• not expressed in developing or adult lung

Pathology

• down-regulated in multiple cancers including:
  • colorectal cancer
  • breast cancer
  • ovarian cancer
  • uterine cancer
  • stomach cancer
  • lung cancer
  • kidney cancer

More general terms

• UNC5 homolog protein
• glycoprotein
• phosphoprotein

Additional terms

• netrin

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=90249
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:90249
• OMIM: https://mirror.omim.org/entry/607869
• UniProt: http://www.uniprot.org/uniprot/Q6ZN44.html