melanoma-associated antigen D1; MAGE-D1 antigen; neurotrophin receptor-interacting MAGE homolog; MAGE tumor antigen CCF (MAGED1, NRAGE, PRO2292, PP2250)

Function

• role in the apoptotic response after nerve growth factor (NGF) binding in neuronal cells
• binds p75NTR & antagonizes its association with TrkA, inhibits cell cycle progression, & facilitates p75NTR- mediated apoptosis
• may act as a regulator of the function of DLX family members
• may regulate p53 transcriptional activity & inhibit cell proliferation
• enhances p53 phosphorylation & accumulation
• interacts with DLX5, DLX7 & MSX2 & forms homomultimers
• interacts with UNC5A (putative)
• interacts with the p75 neurotrophin receptor

Structure

contains 1 MAGE domain

Compartment

• cytoplasm (putative)
• cell membrane, peripheral membrane protein (putative)
• expression shifts from the cytoplasm to the plasma membrane upon stimulation with NGF (putative)

Alternative splicing

named isoforms=2

Expression

• expressed in bone marrow stromal cells from both multiple myeloma patients & healthy donors
• seems to be ubiquitously expressed

More general terms

• melanoma associated antigen (MAGE)
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9500
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9500
• OMIM: https://mirror.omim.org/entry/300224
• UniProt: http://www.uniprot.org/uniprot/Q9Y5V3.html