distal-less homeobox protein-5; homeobox protein DLX-5 (DLX5)

Function

interacts with G22P1 (Ku70)

Structure

• belongs to the distal-less homeobox family
• contains 1 homeobox DNA-binding domain

Compartment

nucleus (putative)

Expression

• 1st expressed in embryos at 8.5-9 days in facial & branchial arch mesenchyme, otic vesicles & frontonasal ectoderm around olfactory placodes
• a day later expression is seen in the developing forebrain in primordia of the ganglionic eminence & ventral diencephalic regions
• in day 12.5 embryos, expressed in the brain & bones, & also in all skeletal structures of midgestation embryos after the 1st cartilage formation
• expression remains unaltered in both brain & skeleton in day 15 embryos & slowly decreases in day 17 embryos

More general terms

• distal-less homeobox protein (DLX)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1749
• OMIM: https://mirror.omim.org/entry/600028
• UniProt: http://www.uniprot.org/uniprot/P56178.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1749