homeobox protein-8; HOX-8; craniosynotosis-associated homeobox protein MSX-2; homeobox protein MSX-2; MSX2 (HOX8)

Function

• probable morphogenetic role
• may play a role in limb-pattern formation
• in osteoblasts, suppresses transcription driven by the osteocalcin FGF response element (OCFRE)
• interacts with MINT (putative)
• interacts with G22P1 (Ku70) & XRCC5 (Ku80)

Structure

• belongs to the Msh homeobox family
• contains 1 homeobox DNA-binding domain

Compartment

nucleus

Pathology

• defects in MSX2 are the cause of
  • parietal foramina 1
  • parietal foramina with cleidocranial dysplasia
  • craniosynostosis type 2

More general terms

• homeobox protein

Database

• UniProt: http://www.uniprot.org/uniprot/P35548.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4488
• OMIM: https://mirror.omim.org/entry/123101
• OMIM: https://mirror.omim.org/entry/168500
• OMIM: https://mirror.omim.org/entry/168550
• OMIM: https://mirror.omim.org/entry/604757